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Genetic Conditions

Genetic Conditions

Conditions caused by gene variations or mutations

Genetic conditions are caused in whole or in part by a change in a person’s DNA sequence. Genetic conditions can be caused by a mutation in one or multiple genes, by a combination of gene mutations and environmental factors, or by damage to chromosomes. Some genetic conditions are inherited, while others occur spontaneously.

Materials for Genetic Conditions

Articles/Research

Genes & Your Health

Description: Basic information on how genetics plays a role in health and disease

Genetic and Rare Conditions

Description: An alphebetical list of genetic disorders

Genetic and Rare Diseases Information Center

Description: The Genetic and Rare Diseases Information Center (GARD) provides access to current, reliable, and easy to understand information about genetic and rare diseases in English and Spanish.

Genetic Conditions

Description: A list of genetic conditions with links to information on each

Genetic Disorders

Description: Information on genetic disorders in general and a listing of resources where further information can be found

Genetic Disorders Library

Description: Detailed information on a variety of genetic conditions

Genomics

Description: General information on genomics and public health

Rare Genetic Disorders - Learning About Genetic Disease Through Gene Mapping, SNPS, and Microarray Data

Description: An article on understanding genetic conditions through the findings of clinical and research genetic tests

Specific Genetic Conditions

Description: Information on a selection of genetic conditions

Studying Genes

Description: An article on genes, biomedical research, and health

What Are Single Gene Disorders?

Description: Single gene disorders are caused by DNA changes in one particular gene, and often have predictable inheritance patterns.

What Is A Genetic Disorder?

Description: A genetic disorder is a disease that is caused by a change, or mutation, in an individual’s DNA sequence.

You and Your Genes Making It in a Tough Environment (PDF 286.80 KB)

Description: An illustrated article on genetic and environmental risks for human disease

Games

DNA Roulette

Description: An odds game that illustrates the probabilistic nature of genomics

Genetic Disease Webquest

Description: A game on genetic diagnosis

Highlights

Lives in the Balance: Why Do We Hold Onto Potentially Harmful, Disease-Causing Mutations?

Description: The persistence of heritable disease raises an evolutionary paradox. When DNA goes awry, and a harmful mutation sprouts up that affects survival, why are these not simply purged from a population over generations?

NHGRI to Fund Programs Promoting Diversity in Genomics

Description: The National Human Genome Research Institute announced that it is seeking grant applications for projects aimed at providing research experiences and skills development in genomics to individuals from underrepresented groups.

Interactive Tutorials

BioDigital Human

Description: The BioDigital Human is a virtual 3D body. This interactive, medically accurate virtual body lets you learn about anatomy, health conditions, and treatments in a visual format that resembles life itself.

Supermodels of Science

Description: Scientists use many different organisms to study diseases in humans. Learn about "model organisms" that help us learn about and find treatments for human diseases.

The Genetics of Resistance to HIV Infection

Description: A detailed interactive tutorial exploring mechanisms of HIV resistance

Teacher Resources

Creating Genetic Counselor Pamphlets (Lesson Plans/Lesson Activities)

Description: After discussing the benefits and potential misuses of prenatal genetic testing, students in grades 9-12 research a particular genetic disorder and then create pamphlets about the disorder from a genetic counselor's point of view.

DNA Repair - Exploring the 2015 Nobel Prize Winning work of two NC scientists (Lesson Plans/Lesson Activities)

Description: Prepared in support of their DNA Day Ambassador visits to schools, this University of North Carolina teaching module explores several built-in protection mechanisms our bodies use to prevent and repair damage to DNA. In 2015, Dr. Aziz Sancar from UNC Chapel Hill and Dr. Paul Modrich from Duke University were awarded the Nobel Prize in Chemistry for their work on understanding DNA repair. Students will extract their own DNA from saliva and analyze REAL data from Dr. Sancars Nobel-winning research.

Exploring Twin Studies (PDF 1,037.91 KB, Lesson Plans/Lesson Activities)

Description: This lesson challenges students to list complex traits, and includes a reading on genetic and environmental influences in type II diabetes. Students are challenged to design a study to determine the relative contribution of environment and genetics for a given trait/condition. Finally, students are introduced to the most common design used for this purpose, the twin study.

From Genomes of Species (PDF 28.17 KB, Lesson Plans/Lesson Activities)

Description: Students create a play, interview a medical patient or doctor, explore advances in genomics at a local university, consider the feasibility and ethical use of bonobos as a model organism.

Personalized Medicine (aka Pharmacogenomics) (Lesson Plans/Lesson Activities)

Description: Prepared in support of their DNA Day Ambassador visits to schools, in this University of North Carolina teaching module students will learn about the concept of personalized medicine; how differences in our genes affect whether a drug treatment will be successful or have serious side effects, and how we can use this information to customize treatments for individual patients. Students will participate in a hands-on activity to further demonstrate how subtle genetic differences affect a patients response to medication.

Retinoblastoma, Cystic Fibrosis, and Body Mass Index, Oh My! (PDF 196.72 KB, Lesson Plans/Lesson Activities)

Description: Building on their intuitive understanding of twin study correlations, students analyze subsets of data to determine how strong the environmental and genetic influences are for three different traits/conditions. Students use mean, standard deviation, and Pearson correlation coefficient to describe and make meaning of their data. They also graph their data and correlations, and compare the results from their subset of data to the results of a group using a different subset of the data.

Technological Advances in Health (Lesson Plans/Lesson Activities)

Description: Students will learn how technology influences human existence by examining the benefits and risks of different biotechnological advances.

Who Gets Sick? (Lesson Plans/Lesson Activities)

Description: Students learn that disease is influenced by genetic factors. They also learn about how the likelihood of inheriting gene mutations for a particular disease is linked to the branches of the human family tree from which one descends.

Video

Molecular Basis of Heredity: Part 3. Genetic Variation

Description: Join Raye Lynn Alford, PhD, as she explains the molecular basis of genetic variation, including mechanisms and types of DNA sequence variations, and patterns of inheritance of genetic disorders.

Telling Stories - Understanding Real Life Genetics

Description: A web-based multi-media education resource that uses real-life stories from the public and professionals to promote knowledge and understanding of genetics and how it impacts on people's lives

The Genome Era: What it Means to You

Description: The director of the National Institutes of Health, Dr. Francis Collins, describes the "genomic research adventure" that is leading to new and more precise ways to diagnose, treat and prevent common and rare genetic diseases. A variety of careers in genomics is presented.

The Pathway to Genomic Medicine

Description: Richard Gibbs, PhD, explains genomic medicine and its role in and relationship to genetic research, and outlines how technology and the study of genetics is transforming medicine.

The Structures of Life

Description: Watch how structural biology gives insight into health, disease, and drug design